I tend to take my first one after I take Lansoprazole with glass of skim milk. This was recomended to me by my Neuro and I also read that it helps somewhere. I suffer IBS attacks, so any effect can be very quick for me. I also eat bananas as part of my breakfast routine. It does seem to help a bit. I started on 30 x 4 per day, and then doubled to 60 x 4 tab's per day. Drinking a little bit of flat zero coke may help too. (For nausea). Tell you pal to keep trying for a week and see. If it still does not settle, then fybogel taken prior to mestinon may help a little. I have some for days when I get IBS due to other tab's I also take. The diabetic ones sometimes contra indicate with the MG one's - but at the end of the day, I have to try and function as best I can and sometimes I have to compromise.